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Adaptive Immunity-Dependent Intestinal Hypermotility Contributes to Host Defense against Giardia spp
- Andersen, Yolanda S., Gillin, Frances D., Eckmann, Lars
- Infection and immunity 2006 v.74 no.4 pp. 2473-2476
- Giardia, animal models, giardiasis, humans, parasites
- Humans infected with Giardia exhibit intestinal hypermotility, but the underlying mechanisms and functional significance are uncertain. Here we show in murine models of giardiasis that small-intestinal hypermotility occurs in a delayed fashion relative to peak parasite burden, is dependent on adaptive immune defenses, and contributes to giardial clearance.