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Immunoglobulin G Antibody Reactivity to a Group A Plasmodium falciparum Erythrocyte Membrane Protein 1 and Protection from P. falciparum Malaria

Author:
Magistrado, Pamela A., Lusingu, John, Vestergaard, Lasse S., Lemnge, Martha, Lavstsen, Thomas, Turner, Louise, Hviid, Lars, Jensen, Anja T.R., Theander, Thor G.
Source:
Infection and immunity 2007 v.75 no.5 pp. 2415-2420
ISSN:
0019-9567
Subject:
Plasmodium falciparum, adaptive immunity, antibodies, children, erythrocytes, genes, immunoglobulin G, malaria, membrane proteins, parasites, pathogenesis, surface antigens
Abstract:
Variant surface antigens (VSA) on the surface of Plasmodium falciparum-infected red blood cells play a major role in the pathogenesis of malaria and are key targets for acquired immunity. The best-characterized VSA belong to the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family. In areas where P. falciparum is endemic, parasites causing severe malaria and malaria in young children with limited immunity tend to express semiconserved PfEMP1 molecules encoded by group A var genes. Here we investigated antibody responses of Tanzanians who were 0 to 19 years old to PF11_0008, a group A PfEMP1. PF11_0008 has previously been found to be highly transcribed in a nonimmune Dutch volunteer experimentally infected with NF54 parasites. A high proportion of the Tanzanian donors had antibodies against recombinant PF11_0008 domains, and in children who were 4 to 9 years old the presence of antibodies to the PF11_0008 CIDR2β domain was associated with reduced numbers of malaria episodes. These results indicate that homologues of PF11_0008 are present in P. falciparum field isolates and suggest that PF11_0008 CIDR2β-reactive antibodies might be involved in protection against malaria episodes.
Agid:
271838