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New Sphingolipids with a Previously Unreported 9-Methyl-C20-sphingosine Moiety from a Marine Algous Endophytic Fungus Aspergillus niger EN-13
- Zhang, Yi, Wang, Song, Li, Xiao-Ming, Cui, Chuan-Ming, Feng, Chao, Wang, Bin-Gui
- Lipids 2007 v.42 no.8 pp. 759-764
- Aspergillus niger, Candida albicans, Phaeophycophyta, endophytes, fungi, spectroscopy, sphingolipids
- Asperamides A (1) and B (2), a sphingolipid and their corresponding glycosphingolipid possessing a hitherto unreported 9-methyl-C₂₀-sphingosine moiety, were characterized from the culture extract of Aspergillus niger EN-13, an endophytic fungus isolated from marine brown alga Colpomenia sinuosa. The structures were elucidated by spectroscopic and chemical methods as (2S,2′R,3R,3′E,4E,8E)-N-(2′-hydroxy-3′-hexadecenoyl)-9-methyl-4,8-icosadien-1,3-diol (1) and 1-O-β-D-glucopyranosyl-(2S,2′R,3R,3′E,4E,8E)-N-(2′-hydroxy-3′-hexadecenoyl)-9-methyl-4,8-icosadien-1,3-diol (2). In the antifungal assay, asperamide A (1) displayed moderate activity against Candida albicans.