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Biodegradation of biphenyl by the ascomycetous yeast Debaryomyces vanrijae

Author:
Lange, J., Hammer, E., Specht, M., Francke, W., Schauer, F.
Source:
Applied microbiology and biotechnology 1998 v.50 no.3 pp. 364-368
ISSN:
0175-7598
Subject:
Debaryomyces, biodegradation, biphenyl, glucose, metabolism, metabolites, yeasts
Abstract:
Cells of the yeast strain Debaryomyces vanrijiae SBUG 770, grown with glucose, converted biphenyl to 4-hydroxybiphenyl as the major metabolite. In addition, 2-hydroxybiphenyl was formed in minor amounts. No further degradation of these substances was detected. However, these monohydroxylated derivatives were oxidised by alkane-grown cells in the presence of the co-metabolic substrate, tetradecane. Under these conditions 2-hydroxybiphenyl was oxidised to 2,5-dihydroxybiphenyl, and 4-hydroxybiphenyl was rapidly metabolised by formation of two major metabolites. One was identified as 3,4-dihydroxybiphenyl. Characterisation of the second product as 4-phenylmuconolactone points to a further metabolism of the initially formed dihydroxylated biphenyl via ortho-ring fission.
Agid:
2755275