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Biotechnology of succinic acid production and markets for derived industrial products
- Zeikus, J.G., Jain, M.K., Elankovan, P.
- Applied microbiology and biotechnology 1999 v.51 no.5 pp. 545-552
- Actinobacillus succinogenes, adipic acid, animals, biodegradability, biotechnology, carbon dioxide, detergents, drugs, electrodialysis, esters, fermentation, glucose, greenhouse gases, industry, ingredients, markets, plant growth, plastics, rumen, solvents, succinic acid, surfactants, tetrahydrofuran
- Succinic acid, derived from fermentation of agricultural carbohydrates, has a specialty chemical market in industries producing food and pharmaceutical products, surfactants and detergents, green solvents and biodegradable plastics, and ingredients to stimulate animal and plant growth. As a carbon-intermediate chemical, fermentation-derived succinate has the potential to supply over 2.7 x 10(8) kg industrial products/year including: 1,4-butanediol, tetrahydrofuran, gamma-bu- tyrolactone, adipic acid, n-methylpyrrolidone and linear aliphatic esters. Succinate yields as high as 110 g/l have been achieved from glucose by the newly discovered rumen organism Actinobacillus succinogenes. Succinate fermentation is a novel process because the greenhouse gas CO2 is fixed into succinate during glucose fermentation. New developments in end-product recovery technology, including water-splitting electrodialysis and liquid/liquid extraction have lowered the cost of succinic acid production to U.S. $0.55/kg at the 75000 tonne/year level and to $2.20/kg at the 5000 tonne/year level. Research directions aimed at further improving the succinate fermentation economics are discussed.