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Mannheimia haemolytica serotype 1 and Pasteurella trehalosi serotype 10 culture supernatants contain fibrinogen-binding proteins
- McNeil, Heather J., Shewen, Patricia E., Lo, Reggie Y.C., Conlon, Jennifer A., Miller, Michael W.
- Veterinary immunology and immunopathology 2002 v.90 no.1-2 pp. 107-110
- Mannheimia haemolytica serotype 1, Pasteurella trehalosi, Western blotting, disease control, fibrinogen, pneumonia, serotypes, virulence
- Fibrinogen-binding proteins were found in the culture supernatants of Mannheimia haemolytica serotype 1 (ATCC 43270) and Pasteurella trehalosi serotype 10 (ECO-100). Sheep fibrinogen was biotinylated and shown to bind to proteins in the culture supernatants by modified western blot. Fibrinogen-binding proteins in the culture supernatant may be important virulence factors leading to the characteristic fibrinous pneumonia caused by these organisms and may be critical antigenic targets for immune prophylaxis.