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Mannheimia haemolytica serotype 1 and Pasteurella trehalosi serotype 10 culture supernatants contain fibrinogen-binding proteins

Author:
McNeil, Heather J., Shewen, Patricia E., Lo, Reggie Y.C., Conlon, Jennifer A., Miller, Michael W.
Source:
Veterinary immunology and immunopathology 2002 v.90 no.1-2 pp. 107-110
ISSN:
0165-2427
Subject:
Mannheimia haemolytica serotype 1, Pasteurella trehalosi, Western blotting, disease control, fibrinogen, pneumonia, serotypes, virulence
Abstract:
Fibrinogen-binding proteins were found in the culture supernatants of Mannheimia haemolytica serotype 1 (ATCC 43270) and Pasteurella trehalosi serotype 10 (ECO-100). Sheep fibrinogen was biotinylated and shown to bind to proteins in the culture supernatants by modified western blot. Fibrinogen-binding proteins in the culture supernatant may be important virulence factors leading to the characteristic fibrinous pneumonia caused by these organisms and may be critical antigenic targets for immune prophylaxis.
Agid:
2783181