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Production of 4-hydroxyphenyllactic acid by Lactobacillus sp. SK007 fermentation
- Mu, Wanmeng, Yang, Yu, Jia, Jianghua, Zhang, Tao, Jiang, Bo
- Journal of bioscience and bioengineering 2010 v.109 no.4 pp. 369-371
- Lactobacillus, antifungal agents, fermentation, tyrosine
- The production of 4-hydroxyphenyllactic acid (4-HO-PLA), a novel antifungal compound, was studied in Lactobacillus sp. SK007 growth. When grown in MRS broth, the strain could produce 75 μg/ml HO-4-PLA, which was the highest reported so far. Tyrosine and 4-hydroxyphenylpyruvic acid (HO-4-PPA) supplements during fermentation could both increase the HO-4-PLA production yield, and the effect of HO-4-PPA on HO-4-PLA production was remarkably better than that of tyrosine. Using HO-4-PPA as substrate could effectively produce HO-4-PLA, which reached 1.26 mg/ml.