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Bovine immunophysiology and genetics: A review of the research and career of Jeanne L. Burton
- Mallard, B.A., McBride, B.W., Kehrli, M.E., Coussens, P.M.
- Veterinary immunology and immunopathology 2009 v.128 no.1-3 pp. 96
- dairy cows, immunity, immunogenetics, researchers, scientists, animal health, animal well-being, quantitative genetics, genomics, disease resistance, bovine mastitis, immune response, endocrine system physiology, somatotropin
- The late Professor Jeanne Burton conducted research related to bovine immunophysiology and immunogenetics, with particular emphasis on the peripartum period when various production stressors are known to negatively impact immunity and alter gene expression patterns. She published over 60 manuscripts in a variety of highly reputable journals, was a sought after conference speaker and known worldwide for her active collaborative efforts. Her 3 most cited manuscripts include: (1) a paper describing the ability of glucocorticoid stress hormones to regulate adhesion molecule expression (l-selectin and CD18) on bovine neutrophils (Burton et al., 1995b). This paper was cited 138 times between 1995 and 2007; (2) a review of the role of bovine somatotropin (Burton et al., 1994b); and (3) a paper describing the effects of supplemental chromium on peripartum immune responses (Burton et al., 1993). Another more recent publication from her graduate student that is also gaining citation, reports the gene expression of blood PMNs from peripartum cows (Madsen et al., 2004). These well-cited publications clearly demonstrate Professor Burton's broad interests within the field of bovine immunobiology. Another career highlight was the Second International Symposium on Animal Functional Genomics (2006) that Dr. Burton organized with Dr. Guilherme Rosa. The symposium brought together leading scientist from around the world studying various aspects of functional genomics. The program included topics such as bioinformatics and the study of genes that underlie reproduction, immune response, disease, growth and metabolism. "We were able to bring the top thought leaders in this discipline together at the symposium, and the program was excellent," Burton said. "The caliber of the symposium led to the special issue of Physiological Genomics, which is a unique way to share this information with the public." The special issue is available online at http://physiolgenomics.physiology.org/. Professor Burton was scheduled to give a presentation entitled, Transcriptome Modifying Effects of Stress on Bovine Leukocytes: Friend or Foe? at the First International Symposium on Animal Genomics of Animal Health Meeting, held in Paris, 23-25 October 2007. This paper was unfortunately not delivered due to her untimely death. Professor Jeanne Burton was an excellent scientist, a wonderful mentor and a dearly loved friend to so many. She will be greatly missed by all her friends from around the world; fortunately, she inspired many to carry the legacy of her research forward.