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T-2 toxicosis and blood coagulation in young chickens

Doerr, J.A., Hamilton, P.B., Burmeister, H.R.
Toxicology and applied pharmacology 1981 v.60 no.2 pp. 157
chickens, young animals, mycotoxicosis, T-2 toxin, dietary exposure, dose response, blood coagulation, blood coagulation factors, thromboplastin, prothrombin, fibrinogen, blood coagulation disorders
Recent reports have suggested that T-2 toxicosis may be a contributing factor in hemorrhagic manifestations such as alimentary toxic aleukia in man and hemorrhagic anemia syndrome and general clotting dysfunction in animals. The present communication describes the effect of graded levels of dietary T-2 toxin (0, 1, 2, 4, 8 and 16 μg/g) on the activities of tissue thromboplastin, coagulation Factors VII, X, and V, prothrombin, and fibrinogen in young chickens. In the extrinsic clotting pathway a qualitative change was demonstrated in the lipid fraction of thromboplastin, and Factor VII activity was significantly (p > 0.05) reduced by the growth inhibitory dose of 4 μg/g. Of the common pathway functions, Factor X, prothrombin, and fibrinogen were depressed by 16 μg/g T-2 toxin, with the latter two parameters being reduced to below 60% of normal. Factor V was unaffected. These data show that T-2 toxin can produce a distinct coagulopathy in chickens characterized by a primary defect in Factor VII activity and secondary effects on prothrombin and fibrinogen. Additionally, the effects of T-2 toxicosis on clotting competence provide further evidence of a possible role of the T-2 toxin in alimentary toxic aleukia.