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Antiobesity effect of trans-10,cis-12-conjugated linoleic acid-producing Lactobacillus plantarum PL62 on diet-induced obese mice

Lee, K., Paek, K., Lee, H.Y., Park, J.H., Lee, Y.
Journal of applied microbiology 2007 v.103 no.4 pp. 1140-1146
Lactobacillus plantarum, adipose tissue, animal disease models, blood, conjugated linoleic acid, foods, glucose, mice, obesity
To observe the antiobesity activity of trans-10,cis-12-conjugated linoleic acid (CLA)-producing lactobacillus in mice. Lactobacillus plantarum PL62, which can grow in the presence of linoleic acid, was selected and studied. The culture supernatant of Lact. plantarum PL62 contained trans-10,cis-12-conjugated linoleic acid (6·4 μg ml⁻¹), and the crude enzyme prepared from washed cells produced trans-10,cis-12 CLA (1395 μg mg⁻¹ protein). Lact. plantarum PL62 reduced the weights of epididymal, inguinal, mesenteric, and perirenal white adipose tissues and significantly reduced the blood levels of total glucose and body weights of mice (P < 0·01). trans-10,cis-12-CLA-producing Lact. plantarum PL62 can exert the same antiobesity activity as trans-10,cis-12-CLA in mice. trans-10,cis-12-CLA-producing Lactobacillus can be a replacement for CLA for obesity treatment via the continuous production of trans-10,cis-12-CLA. The results provide a novel opportunity to develop foods with antiobesity activity.