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Acute effect of Butea superba Roxb. extract on intracavernous pressure and blood pressure in adult male rats

Author:
Smitasiri, Y., Pinmongkholgul, S.
Source:
Acta horticulturae 2014 no.1023 pp. 149-153
ISSN:
0567-7572
Subject:
Butea, adults, blood pressure, cortex, males, oral administration, plant extracts, rats, roots, stele, traditional medicine
Abstract:
Butea superb (BS) root has been used for Thai traditional medicine. It was believed for its sexual performance increasing property in aged person. There was a report that administration of B. superba root ethanolic extract orally everyday for a period of time to male rats could induce penile erection by increasing intracavernous pressure. However, acute effect of the single oral administration of ethanolic extracts from various parts of BS root on intracavernous pressure and blood pressure in adult male rat had not been investigated. Then the objective of this project was to investigate the acute effect of single administration of three dosages of ethanolic extract from fresh or dried stele of BS roots or fresh or dried cortex of BS roots at the dosage of 1, 10 and 100 mg kg-1 orally on intracavernous pressure and blood pressure in adult male Sprague Dawley rats were measured during anaesthetized condition. It was found that one-hour after single administration of every dosages of ethanolic extract from fresh or dried stele of BS roots or fresh or dried cortex of BS roots to adult male rats could significantly increase the intracavernous pressure without altering blood pressure, both systolic and diastolic. Low dosage of ethanolic extract of each BS root studied, seem to increase intracavernous pressure more effectively than the high dosage used. It was concluded that one-hour after treatment of BS extract could induce intracavernous pressure without altering blood pressure in adult male rats and low dosage of BS extract was more effective.
Agid:
2937208