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LipA, a Tyrosine and Lipid Phosphatase Involved in the Virulence of Listeria monocytogenes

Author:
Kastner, Renate, Dussurget, Olivier, Archambaud, Cristel, Kernbauer, Elisabeth, Soulat, Didier, Cossart, Pascale, Decker, Thomas
Source:
Infection and immunity 2011 v.79 no.6 pp. 2489-2498
ISSN:
0019-9567
Subject:
Listeria monocytogenes, bacteria, enzyme activity, enzymes, genes, pathogens, signal transduction, tyrosine, virulence
Abstract:
Intracellular bacterial pathogens manipulate host cell functions by producing enzymes that stimulate or antagonize signal transduction. The Listeria monocytogenes genome contains a gene, lmo1800, encoding a protein with a conserved motif of conventional tyrosine phosphatases. Here, we report that the lmo1800-encoded protein LipA is secreted by Listeria and displays tyrosine as well as lipid phosphatase activity in vitro. Bacteria lacking LipA are severely attenuated in virulence in vivo, thus revealing a so-far-undescribed enzymatic activity involved in Listeria infection.
Agid:
294678