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Addition of N-acetylcysteine to linoleic acid hydroperoxide

Author:
Gardner, H.W., Weisleder, D., Kleiman, R.
Source:
Lipids 1976 v.11 no.2 pp. 127
ISSN:
0024-4201
Subject:
acetylcysteine, linoleic acid, hydroperoxides, chemical reactions, isomers
Abstract:
Catalyzed by 10(-5)M ionic iron in 80% ethanol, N-acetylcysteine added to linoleic acid hydroperoxide, forming a thiobond. Reaction of a specific isomer of hydroperoxide, 13-hydroperoxy-trans-11, cis-9-octadecadienoic acid, and N-acetylcysteine, forms a number of products, of which two were identified as addition compounds. One addition product was 9-S-(N-acetylcysteine)-13-hydroxy-10-ethoxy-trans-11-octadecenoic acid, and the other was 9-S-(N-acetylcysteine)-10, 13-dihydroxy-trans-11-octadecenoic acid.
Agid:
29711
Handle:
10113/29711