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A Rab32-Dependent Pathway Contributes to Salmonella Typhi Host Restriction
- Spanò, Stefania, Galán, Jorge E.
- Science 2012 v.338 no.6109 pp. 960-963
- Salmonella Typhi, humans, macrophages, mice, pathogens, secretion, typhoid fever
- Removing Typhoid Restriction Some bacterial pathogens exhibit exquisite host adaptation and can only infect a single host. For example, Salmonella enterica serovar Typhi (S. Typhi), the cause of typhoid fever, can only infect humans. The host restriction is manifested at the cellular level because S. Typhi is unable to survive within macrophages of species other than human. Spanò and Galán (p. 960) found that expression of a single type-III secretion effector protein from a broad host Salmonella in S. Typhi, allowed this human-exclusive pathogen to survive within macrophages from a nonpermissive host. Furthermore, S. Typhi expressing this effector was able to replicate within mice, a nonpermissive host.