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Changes in rRNA Transcription Influence Proliferation and Cell Fate Within a Stem Cell Lineage
- Zhang, Qiao, Shalaby, Nevine A., Buszczak, Michael
- Science 2014 v.343 no.6168 pp. 298-301
- DNA-directed RNA polymerase, Drosophila, animal ovaries, cell differentiation, germ cells, mammals, plant ovary, ribosomal RNA, stem cells, yeasts
- Germline Pol I RNA polymerase I (Pol I)–directed ribosomal RNA (rRNA) transcription has been extensively studied in mammalian cell lines and yeast. However, the functional significance of cell-specific regulation of Pol I transcription within developmental contexts in vivo remains unclear. Zhang et al. (p. 298) characterized a Drosophila Pol I regulatory complex and found that germline stem cells (GSCs) of the ovary exhibited increased levels of rRNA transcription relative to their immediate daughter cells. High levels of rRNA expression promoted GSC proliferation, with attenuation of Pol I activity showing effects during early germ cell differentiation.