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Genetic analysis of renal function in mice. 1. Glomerular filtration rate and its correlation with body and kidney weight
- Hackbarth, H., Hackbarth, D.
- Laboratory animals 1981 v.15 no.3 pp. 267-272
- allometry, analysis of covariance, body weight, genetic analysis, glomerular filtration rate, heat production, kidneys, laboratory animals, males, mice
- Investigation of 18 inbred and 6 F₁ hybrid mouse strains has shown that the glomerular filtration rate, bodyweight and kidney weight showed strain- and sex-dependent differences. Covariance analysis showed stronger correlations (genetic and environmental) between glomerular filtration rate and bodyweight than between glomerular filtration rate and kidney weight. This was predominantly due to a high within-strain variation of kidney weight (56%) in male mice. Therefore an allometric regression was calculated between the 48 strain means of glomerular filtration rate (GFR) and bodyweight (BW): GFR = 0·036 × BW⁰·⁷⁴ Thus the term BW⁰·⁷⁴ a suitable correction term for comparing the heat production of different species, is also suitable for the correction of glomerular filtration rate within one species.