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Effects of a dietary application of a yeast cell wall extract on innate and acquired immunity, on oxidative status and growth performance in weanling piglets and on the ileal epithelium in fattened pigs

Author:
Sauerwein, H., Schmitz, S., Hiss, S.
Source:
Journal of animal physiology and animal nutrition 2007 v.91 no.9-10 pp. 369-380
ISSN:
0931-2439
Subject:
Saccharomyces cerevisiae, T-lymphocytes, adaptive immunity, antioxidant activity, cell walls, epithelium, feed intake, growth performance, haptoglobins, ileum, immunoglobulin A, immunoglobulin M, immunohistochemistry, immunomodulation, neutrophils, oxidative stress, phagocytosis, piglets, reactive oxygen species, slaughter, swine feeding, weanlings, yeasts
Abstract:
Potential immunomodulatory effects of a cell wall extract from Saccharomyces cerevisiae (Y; Antaferm MG) were tested in pigs: in trial I, 0.03% Y and in trial II 0.3% Y was used. Based on earlier observations that Y may increase feed intake, two treatment groups, Y-a (fed ad libitum) and Y-r (fed restrictively) were studied in comparison with a control group (C) in both trials. Y-r received the amount of feed consumed by C. Immune status was surveyed by determining phagocytic activity and oxidative burst of neutrophils and blood concentrations of haptoglobin (Hp), and immunoglobulin (Ig) G and A. Oxidative stress was monitored by recording reactive oxygen metabolites (ROM) and total antioxidant capacity. In a third trial, fattened pigs were used for morphological and immunohistochemical studies (IgM and IgA as well as CD [graphic removed] and CD [graphic removed] T cells) in ileal epithelium. Pigs fed 0.03% Y for 2 weeks prior to slaughter were compared with the C group. Feed intake was identical in the Y-a and Y-b groups and data subsets were accordingly pooled. Treatment and time as well as treatment x time interactions were detectable for most of the parameters studied, but a distinct immunomodulatory effect of Y was not consistently identifiable and performance did not improve. In trial III, the intestinal parameters investigated were not different between Y and C.
Agid:
3104043