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Functions of chitosan-ferulic acid salt for prevention of hypertension
- Murata, Yoshifumi, Nagaki, Kumiko, Kofuji, Kyoko, Kishi, Toshihiro
- Food science and technology research 2010 v.16 no.5 pp. 437-442
- adsorption, antihypertensive effect, bile acids, body weight, chitosan, food intake, gastric juice, gels, hypertension, pectins, rats, systolic blood pressure
- A chitosan (CS)-ferulic acid (FA) salt was prepared. FA release from CS-FA and bile acid (BA) adsorption by CS-FA were investigated in vitro. CS-FA released FA into artificial gastric juice or a medium containing BA. Two functions were recognized on alginate or pectin gel beads containing CS-FA: FA release and BA adsorption. Anti-hypertensive effects of CS, FA or CS-FA on hypertensive rats were tested. In rats given a diet containing CS-FA or FA, elevation of systolic blood pressure was suppressed compared to the control diet group, but no difference in food intake or body weight was observed between groups.