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Unusual 9,19 : 24,32-Dicyclotetracyclic Triterpenoids from Lygodium japonicum

Author:
Han, Qing-hua, Liu, Xin, Yao, Wen-qing, Cheng, Zhong-bin, Lin, Ting-ting, Song, Ching, Yin, Sheng
Source:
Planta medica 2012 v.78 no.18 pp. 1971-1975
ISSN:
0032-0943
Subject:
Lygodium japonicum, agonists, grasses, humans, kidneys, liver, skeleton, spectroscopy, triterpenoids
Abstract:
Lygodipenoids A (1) and B (2), two novel C33 tetracyclic triterpenoids with a new 9,19 : 24,32-dicyclopropane skeleton, were isolated from the whole grass of Lygodium japonicum. Their structures were elucidated by spectroscopic and chemical means. Compounds 1 and 2 were tested in transfected cultured human embryonic kidney 293 HEK293 cells for an agonist assay, and compound 1 was identified as a partial agonist for liver X receptor α.
Agid:
316725