Jump to Main Content
Pharmacokinetic Characteristics of Capsaicin-Loaded Nanoemulsions Fabricated with Alginate and Chitosan
- Choi, Ah Young, Kim, Chong-Tai, Park, Hee Yoon, Kim, Han Oll, Lee, Na Ra, Lee, Kyung
Eun, Gwak, Hye Sun
- Journal of agricultural and food chemistry 2013 v.61 no.9 pp. 2096-2102
- Capsicum, bioavailability, capsaicin, chitosan, nanoemulsions, pharmacokinetics, polymers, rats
- Nanotechnologies are being employed to enhance the stability and oral bioavailability of lipophilic substances, such as capsaicin. This study aimed to examine the pharmacokinetic properties of the formulated capsaicin-loaded nanoemulsions. A pharmacokinetic study was carried out using double-layer nanoemulsions fabricated with alginate and chitosan polymers and triple-layer nanoemulsions fabricated with chitosan/alginate polymers. Capsaicin nanoemulsions and capsaicin control (oleoresin capsicum) were administered to the rat at a dose of 10 mg/kg. A statistically significant difference was found in the area under the curve from time zero to time infinity (AUCᵢₙf) among formulations (p < 0.01). In comparison to the control group, the relative bioavailability of formulated nanoemulsions was up to 131.7. The AUCᵢₙf increased in a nano-size-dependent manner; as nano size decreased, AUCᵢₙf increased. IN comparison to the double-layer nanoemulsions, the triple-layer nanoemulsion showed a significantly increased volume of distribution, resulting in the increased clearance and decreased AUCᵢₙf. It was concluded that the formulated nanoemulsions could significantly enhance the bioavailabilty of capsaicin.