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Evaluation of glomerular filtration rate in cats with reduced renal mass and administered meloxicam and acetylsalicylic acid
- Surdyk, Kathryn K., Brown, Cathy A., Brown, Scott A.
- American journal of veterinary research 2013 v.74 no.4 pp. 648-651
- adults, aspirin, blood serum, cats, creatinine, glomerular filtration rate, meloxicam, normal values, placebos, prostaglandin synthase, uremia, urine
- Objective-To determine whether administration of meloxicam or acetylsalicylic acid alters glomerular filtration rate (GFR) in cats with renal azotemia. Animals-6 young adult cats. Procedures-3 sexually intact male cats and 3 sexually intact female cats had surgically reduced renal mass and azotemia comparable to International Renal Interest Society chronic kidney disease stages 2 and 3. Renal function was evaluated by measurement of serum creatinine concentration, urinary clearance of exogenously administered creatinine, and the urine protein-to-creatinine concentration ratio (UP:C). Measurements taken in cats receiving placebo at the beginning and end of the study were compared with results obtained at the end of 7 days of treatment with either meloxicam (0.2 mg/kg, SC, on day 1; 0.1 mg/kg, SC, on days 2 to 7) or acetylsalicylic acid (20 mg/kg, PO, on days 1, 4, and 7). Results-No significant treatment effects on urinary clearance of exogenously administered creatinine, serum creatinine concentration, or UP:C were detected. Mean ± SEM serum creatinine concentration and urinary clearance of exogenously administered creatinine measurements following 7 days of treatment with meloxicam (serum creatinine concentration, 2.67 +/- 0.17 mg/dL; urinary clearance of exogenously administered creatinine, 1.34 +/- 0.08 mL/min/kg) and acetylsalicylic acid (serum creatinine concentration, 2.62 +/- 0.12 mg/dL; urinary clearance of exogenously administered creatinine, 1.35 +/- 0.07 mL/min/kg) were not significantly different from the mean baseline values for these variables (serum creatinine concentration, 2.77 +/- 0.14 mg/dL; urinary clearance of exogenously administered creatinine, 1.36 +/- 0.07 mL/min/kg). Conclusions and Clinical Relevance-Neither meloxicam nor acetylsalicylic acid had a measurable effect on urinary clearance of exogenously administered creatinine, serum creatinine concentration, or UP:C. These results are consistent with the hypothesis that GFR of euvolemic cats with normal or reduced renal function is not dependent on cyclooxygenase function.