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Le stress oxydatif et la bpco: polymorphisme des glutathion-s-transferases et apport de la phytotherapie clinique
- Lakhdar, R., Denden, S., Kassab, A., Leban, N., Daimi, H., Kahloun, H., Hergli, A., Knani, J., Miled, A., Haj Khelil, A., Ben Chibani, J.
- Acta horticulturae 2013 no.997 pp. 251-256
- Daucus carota, Ginkgo, Rosa canina, Silybum marianum, air, air flow, antioxidants, diabetes, fruits, genes, genotype, green tea, herbal medicines, hospitals, oxidative stress, patients, phytotherapy, pollutants, proteins, respiratory system, roots, tobacco, toxins, trace elements, vitamins, Tunisia
- The oxidative stress is incriminated as cause or consequence of numerous pathologies such as, the inflammatory syndromes, cancer, diabetes, as well as in chronic obstructive pulmonary disease (COPD). Researches were developed on the biological, clinical and molecular exploration of COPD. This pathology is characterized by an airflow limitation that is not fully reversible. Consequently, we attend an important back keeping of numerous environmental toxins in the respiratory system. The measures of personal exposure to tobacco smoke, dusts and professional chemicals, as well as internal and external air pollutants reduction are important objectives in the primary and secondary prevention of CPOD. The system purifying oxidative stress is complex. It includes enzymatic and non-enzymatic ways. Among the enzymatic families, the glutathione-S-transferases constitute an important agent of detoxification. The analysis of polymorphisms of genes coding these proteins was undertaken in the perspective of the research for a positive correlation with the oxidative stress. In COPD patients sample followed in hospitals of Central Tunisia, we detected an association of genotypes null-allele GSTM1 (p=0,02) and Val105/Val105 GSTP1 (p=0,001) with the development of the pathology. Besides in the prospect to contribute to the preventive efforts and to the improvement of the therapeutic solutions, we led an investigation with the followers of the clinical herbal medicine. Some plants facilitate the hepatic detoxification and several species are recommended for that purpose. We distinguish plants with vitamins and rich in trace elements (roots of Daucus carota, fruits of Rosa canina). We also privilege plants to active antioxidant principles as the ginkgo (ginkgolides, bilobalides), the thistle marries Silybum marianum (sylimarine) and even green tea (epigallocatechines).