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Galacto-oligosaccharides Derived from Lactulose Exert a Selective Stimulation on the Growth of Bifidobacterium animalis in the Large Intestine of Growing Rats

Author:
Marín-Manzano, M. Carmen, Abecia, Leticia, Hernández-Hernández, Oswaldo, Sanz, M. Luz, Montilla, Antonia, Olano, Agustín, Rubio, Luis A., Moreno, F. Javier, Clemente, Alfonso
Source:
Journal of agricultural and food chemistry 2013 v.61 no.31 pp. 7560-7567
ISSN:
1520-5118
Subject:
Bifidobacterium animalis, Clostridium coccoides, Eubacterium rectale, cecum, colon, diet, functional foods, galactooligosaccharides, intestinal microorganisms, lactose, lactulose, rats
Abstract:
There is increasing interest in identifying novel dietary nondigestible carbohydrates capable of modulating the composition and/or metabolic activities of the gut microbiota. This work assessed the differential modulatory influence of novel galacto-oligosaccharides derived from lactulose (GOS-Lu) in comparison with commercial galacto-oligosaccharides derived from lactose (GOS-La) in gut microbiota of growing rats (5 weeks old). Rats were fed either a control diet or diets containing 1% (w/w) of GOS-Lu or GOS-La, and cecal and colonic contents were collected after 14 days of treatment. Compared to controls, GOS-Lu had significantly more bifidobacteria within the large intestine, showing a significant and selective increase of Bifidobacterium animalis in the cecum and colon; however, no significant differences in the number of bifidobacteria among GOS-Lu and GOS-La groups were observed. Both types of GOS significantly increased the number of the Eubacterium rectale/Clostridium coccoides group. These findings support a prebiotic role of galactosyl-fructoses in functional foods.
Agid:
322204