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Consumption of Cherries Lowers Plasma Urate in Healthy Women

Author:
Jacob, Robert A., Spinozzi, Giovanna M., Simon, Vicky A., Kelley, Darshan S., Prior, Ronald L., Hess-Pierce, Betty, Kader, Adel A.
Source:
Journal of nutrition 2003 v.133 no.6 pp. 1826-1829
ISSN:
0022-3166
Subject:
C-reactive protein, Prunus avium, albumins, antioxidants, ascorbic acid, blood, cherries, creatinine, dehydroascorbic acid, excretion, fruits, nitric oxide, tumor necrosis factor-alpha, urine, women
Abstract:
To assess the physiologic effects of cherry consumption, we measured plasma urate, antioxidant and inflammatory markers in 10 healthy women who consumed Bing sweet cherries. The women, age 22-40 y, consumed two servings (280 g) of cherries after an overnight fast. Blood and urine samples were taken before the cherry dose, and at 1.5, 3 and 5 h postdose. Plasma urate decreased 5 h postdose, mean ± sem = 183 +/- 15 μmol/L compared with predose baseline of 214 +/- 13 μmol/L (P < 0.05). Urinary urate increased postdose, with peak excretion of 350 +/- 33 μmol/mmol creatinine 3 h postdose compared with 202 +/- 13 at baseline (P < 0.01). Plasma C-reactive protein (CRP) and nitric oxide (NO) concentrations had decreased marginally 3 h postdose (P < 0.1), whereas plasma albumin and tumor necrosis factor-α were unchanged. The vitamin C content of the cherries was solely as dehydroascorbic acid, but postdose increases in plasma ascorbic acid indicated that dehydroascorbic acid in fruits is bioavailable as vitamin C. The decrease in plasma urate after cherry consumption supports the reputed anti-gout efficacy of cherries. The trend toward decreased inflammatory indices (CRP and NO) adds to the in vitro evidence that compounds in cherries may inhibit inflammatory pathways.
Agid:
325264