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Antioxidant Action of Moringa oleifera Lam. (Drumstick) Against Antitubercular Drugs Induced Lipid Peroxidation in Rats

Author:
Kumar, N. Ashok, Pari, L.
Source:
Journal of medicinal food 2003 v.6 no.3 pp. 255-259
ISSN:
1096-620X
Subject:
protective effect, peroxides, glutathione, drug therapy, liver, Moringa oleifera, catalase, glutathione transferase, lipid peroxidation, rifampicin, superoxide dismutase, glutathione peroxidase, isoniazid, silymarin, toxicity, rats, antioxidant activity, ascorbic acid
Abstract:
The protective effect of Moringa oleifera Lam. (Moringaceae) on hepatic marker enzymes, lipid peroxidation, and antioxidants was investigated during antitubercular drug (isoniazid, rifampicin, and pyrazinamide)-induced toxicity in rats. Enhanced hepatic marker enzymes and lipid peroxidation of antitubercular drug treatment was accompanied by a significant decrease in the levels of vitamin C, reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase. Administration of Moringa oleifera extract and silymarin significantly decreased hepatic marker enzymes and lipid peroxidation with a simultaneous increase in the level of antioxidants. We speculate that Moringa oleifera extract exerts its protective effects by decreasing liver lipid peroxides and enhancing antioxidants.
Agid:
325632