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Chromosomal directionality of DNA mismatch repair in Escherichia coli
- Hasan, A. M. Mahedi, Leach, David R. F.
- Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.30 pp. 9388-9393
- DNA repair, DNA replication, Escherichia coli, bacteria, base pair mismatch, chromosomes, death, genetic disorders, humans, neoplasms
- DNA mismatch repair (MMR) is critical to avoid mutations that can lead to genetic disease, cancer, and death. The MMR system is evolutionarily conserved from bacteria to humans and is an example of a remarkable molecular machine. Here we show that this machine operates unidirectionally with respect to the chromosome of Escherichia coli. The most likely explanation for this directionality is that the MMR machinery is associated with the complex responsible for DNA replication. We suggest that this association facilitates the mechanism of strand discrimination in MMR.