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Archaeal actin from a hyperthermophile forms a single-stranded filament

Author:
Braun, Tatjana, Orlova, Albina, Valegård, Karin, Lindåås, Ann-Christin, Schrååöder, Gunnar F., Egelman, Edward H.
Source:
Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.30 pp. 9340-9345
ISSN:
0027-8424
Subject:
Archaea, actin, eukaryotic cells
Abstract:
Actin is one of the most abundant and highly conserved eukaryotic proteins, but the basis for the exquisite sequence conservation in actin is not known. In contrast, bacterial actin-like proteins display almost no sequence conservation and form very different filaments. We have examined the filaments formed by an actin-like protein in the third kingdom of life, Archaea, and although they only have a single strand, the strand is very similar to each of the two strands in actin. This gives previously unidentified insights into the divergence of archaea and eukaryotes.
Agid:
3387306