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Distinct speed dependence of entorhinal island and ocean cells, including respective grid cells

Author:
Sun, Chen, Kitamura, Takashi, Yamamoto, Jun, Martin, Jared, Pignatelli, Michele, Kitch, Lacey J., Schnitzer, Mark J., Tonegawa, Susumu
Source:
Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.30 pp. 9466-9471
ISSN:
0027-8424
Subject:
calcium, cortex, fluorescence, hippocampus, image analysis, islands, mice, oceans
Abstract:
The importance of entorhinal–hippocampal circuits in the mammalian brain for an animal’s spatial and episodic experience is known, but the neural basis for these different spatial computations is unclear. Medial entorhinal cortex layer II contains island and ocean cells that project via separate pathways into hippocampus. We performed Ca ²⁺ imaging in freely exploring mice using cellular markers and a miniature head-mounted fluorescence microscope, the first time (to our knowledge) in entorhinal cortex. We found that, although both oceans and islands contain grid cells, islands are significantly more speed modulated than oceans. We speculate that this differential property reflects islands’ and oceans’ contribution to different downstream functions.
Agid:
3387324