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Effect of cultivation conditions on production of secondary metabolites by Penicillium citrinum
- Antipova, T. V., Zhelifonova, V. P., Kozlovsky, A. G.
- Microbiology 2015 v.84 no.3 pp. 365-369
- Penicillium citrinum, carbon, ergot alkaloids, fungi, secondary metabolites, sodium chloride, temperature
- Medium composition, cultivation temperature, and pO₂ had a regulatory effect on production of ergot alkaloids (EA) and quinocitrinines (QC) by the fungal strain Penicillium citrinum VKM F-4043 D. Maximal accumulation of EA and QC occurred at 24 and 28°C, respectively. Maximal EA synthesis occurred at 40% pO₂, while at 10–20% the conditions were optimal for QC synthesis. Production of these metabolites depended directly on the concentration of the carbon source in the medium. Addition of 2.5% NaCl did not inhibit EA and QC accumulation.