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Gastroprotective and Antioxidant Potential of Methanol Root Extract of Taverniera cuneifolia (Roth) Arn. in Albino Wister Rat

Jamdhade, Vijay C., Tembhurne, S.V., Kamble, Suresh, Surwase, Babasaheb S.
Journal of Biologically Active Products from Nature 2015 v.5 no.2 pp. 150-162
DNA damage, Taverniera, acidity, albino, antioxidant activity, ethanol, free radical scavengers, methanol, models, nitric oxide, pylorus, rats, roots, solvents, stomach ulcers, thiobarbituric acid-reactive substances
To investigate the gastro protective and antioxidant activities of methanolic extract of Taverniera cuneifolia (Roth) Arn. Gastric ulcers were produced by administration of ethanol and pylorus ligation in albino Wister rats. Free radical scavenging activity was evaluated by using DPPH, Nitric oxide, DNA Damage Scavenging methods. Taverniera cuneifolia extract treated group decreased the dose dependently gastric content, acidity, ulcer index and TBARS of gastric content. In this study the DPPH and Nitric oxide radical is significantly reduced by solvent extract and standard with increasing concentration. The maximum prevention of DNA damage was found at 4 µg/ml concentration. The gastro protective property of methanolic extract of Taverniera cuneifolia in pylorus ligation model has been demonstrated to reduce the number of ulcer and ulcer index. The present study suggests that methanolic extract of Taverniera cuneifolia roots are beneficial in the treatment of gastric ulcer.