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Assessment of coagulation utilizing thromboelastometry in dogs undergoing orthopedic surgery

Bruno, Barbara, Maurella, Cristiana, Falco, Sara, Tarducci, Alberto, Zanatta, Renato, Gianella, Paola, D'Angelo, Antonio, Piras, Lisa, Di Bella, Andrea, Borrelli, Antonio
Journal of veterinary emergency and critical care 2015 v.25 no.3 pp. 358-363
adults, blood, blood coagulation, citrates, coagulation, dogs, firmness, humans, orthopedics, patients, surgery
OBJECTIVE: To evaluate blood coagulation using thromboelastometry in dogs following orthopedic surgery. DESIGN: Longitudinal observational study. SETTING: University veterinary teaching hospital. ANIMALS: Thirty‐four adult client‐owned dogs. MEASUREMENTS AND MAIN RESULTS: Dogs undergoing elective or emergency orthopedic surgery had whole blood collected before (T0), at 24 hours (T1), and 1 week (T2) after surgery. Whole blood from each dog was collected by jugular venipuncture using a 20‐Ga needle and minimum venous stasis. The blood was placed into tubes containing 3.8% trisodium citrate (1 part citrate: 9 parts blood) and rested at 37°C. Coagulation was evaluated by means of thromboelastometry using the in‐TEM, ex‐TEM, and fib‐TEM assays. Statistically significant increases (P < 0.05) in maximum clot firmness (MCF) from T0 to T1 in the in‐TEM and fib‐TEM profiles (both P = 0.0001), from T0 to T2 in the in‐TEM, ex‐TEM, and fib‐TEM profiles (P = 0.012, P = 0.037, and P = 0.0001, respectively), and from T1 to T2 in the fib‐TEM profile (P = 0.039) were noted. The α angle increased from T0 to T2 in the in‐TEM and ex‐TEM profiles (P = 0.019 and P = 0.036, respectively). All results were, however, within the institutional reference ranges. CONCLUSIONS: In this study, unlike the hypercoagulability observed in human orthopedic patients, a hypercoagulable state as measured by thromboelastometry did not develop in dogs following orthopedic surgery.