U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

The effects of creatine supplementation on cardiovascular, metabolic, and thermoregulatory responses during exercise in the heat in endurance-trained humans

Author:
Kilduff, L.P., Georgiades, E., James, N., Minnion, R.H., Mitchell, M., Kingsmore, D., Hadjicharlambous, M., Pitsiladis, Y.P.
Source:
International journal of sport nutrition & exercise metabolism 2004 v.14 no.4 pp. 443-460
ISSN:
1526-484X
Subject:
ambient temperature, creatine, exercise, exercise test, glucose, heart rate, heat, humans, males, metabolism, placebos, polymers, sports nutrition, sweat
Abstract:
The effects of creatine (Cr) supplementation on cardiovascular, metabolic, and thermoregulatory responses, and on the capacity of trained humans to perform prolonged exercise in the heat was examined. Endurance-trained males (n = 21) performed 2 constant-load exercise tests to exhaustion at 63 ± 5 % VO(2max) in the heat (ambient temperature: 30.3 ± 0.5 °C) before and after 7 d of Cr (20 g · d-1 Cr + 140 g · d-1 glucose polymer) or placebo. Cr increased intracellular water and reduced thermoregulatory and cardiovascular responses (e.g., heart rate, rectal temperature, sweat rate) but did not significantly increase time to exhaustion (47.0 ± 4.7 min vs. 49.7 ± 7.5 min, P = 0.095). Time to exhaustion was increased significantly in subjects whose estimated intramuscular Cr levels were substantially increased ("responders": 47.3 ± 4.9 min vs. 51.7 ± 7.4 min, P = 0.031). Cr-induced hyperhydration can result in a more efficient thermoregulatory response during prolonged exercise in the heat.
Agid:
3650397