Jump to Main Content
β-Arrestins: multifunctional signaling adaptors in type 2 diabetes
- Feng, Xiaotao, Wang, Wenjian, Liu, Jibo, Liu, Yi
- Molecular biology reports 2011 v.38 no.4 pp. 2517-2528
- insulin, noninsulin-dependent diabetes mellitus, proteins, signal transduction
- β-Arrestins are not only well-known negative regulators of G protein-coupled receptor (GPCR) signaling, but also important adaptors in modulating the strength and duration of cellular signaling by scaffolding and interacting with a lot of cytoplasmic proteins. While β-arrestins are rather well described signal-mediated molecules, they are not generally associated with insulin signaling. But recent work has confirmed the difference from original thought. The current review aims to explore the emerging roles for β-arrestins in regulating insulin action, inflammatory signal pathway and other cellular signaling which are associated with type 2 diabetes.