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β-Arrestins: multifunctional signaling adaptors in type 2 diabetes

Author:
Feng, Xiaotao, Wang, Wenjian, Liu, Jibo, Liu, Yi
Source:
Molecular biology reports 2011 v.38 no.4 pp. 2517-2528
ISSN:
0301-4851
Subject:
insulin, noninsulin-dependent diabetes mellitus, proteins, signal transduction
Abstract:
β-Arrestins are not only well-known negative regulators of G protein-coupled receptor (GPCR) signaling, but also important adaptors in modulating the strength and duration of cellular signaling by scaffolding and interacting with a lot of cytoplasmic proteins. While β-arrestins are rather well described signal-mediated molecules, they are not generally associated with insulin signaling. But recent work has confirmed the difference from original thought. The current review aims to explore the emerging roles for β-arrestins in regulating insulin action, inflammatory signal pathway and other cellular signaling which are associated with type 2 diabetes.
Agid:
382000