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A novel human derived cell-penetrating peptide in drug delivery

Author:
Zhao, Jian, Gao, Peng, Xiao, Wei, Fan, Li-Qiang, Wang, Fu-Jun, Li, Su-Xia, Liu, Jian-Wen
Source:
Molecular biology reports 2011 v.38 no.4 pp. 2649-2656
ISSN:
0301-4851
Subject:
anticarcinogenic activity, drugs, fluorescence microscopy, humans, superoxide dismutase
Abstract:
Cell-penetrating peptides can carry a variety of biologically active molecules into cells. Here we have identified a novel CPP derived from the C-terminus of human extracellular superoxide dismutase (hC-SOD3) which was shown to be located throughout in the cytoplasm and nucleus by fluorescence microscopy investigation. Furthermore, when apoptin fused to hC-SOD3, it was translocated efficiently into HeLa cells resulting in antitumor activities. This study shows that hC-SOD3 has the potential to penetrate and translocate cargo molecules into cells and has no cytotoxicity at effective concentration.
Agid:
382016