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Avenanthramides are bioavailable and accumulate in hepatic, cardiac, and skeletal muscle tissue following oral gavage in rats

Author:
Koenig, Ryan T., Dickman, Jonathan R., Wise, Mitchell L., Ji, Li Li
Source:
Journal of agricultural and food chemistry 2011 v.59 no.12 pp. 6438-6443
ISSN:
1520-5118
Subject:
Avena sativa, bioavailability, blood circulation, heart, high performance liquid chromatography, ingestion, liver, oats, rats, skeletal muscle
Abstract:
Avenanthramides (AVA), polyphenols found exclusively in oats (Avena sativa L.), may play a role in the anti-inflammatory and antiatherogenic activity of oats. The bioavailability of AVA has been demonstrated previously, but its distribution at the organ and tissue level and the extent of conjugation following ingestion have been unexplored. Synthetic AVA was administered to 24 rats by oral gavage, whereas 6 control rats received saline. AVA concentrations were measured via HPLC in plasma, liver, heart, and gastrocnemius (GAS) obtained over a 12 h period (0, 2, 4, 12 h; n = 6 at each time point). Samples were extracted with and without glucuronidase-sulfatase to assess the level of conjugation. We conclude that AVA are bioavailable to the blood circulation following oral ingestion in the rat and reach peripheral tissues where they can be taken up by various organs differentially. With AVA remaining in the organs for up to 12 h, it seems possible to maintain an increased level of AVA in the rat via repeated feedings.
Agid:
382614