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Possible role for apple juice phenolic compounds in the acute modification of glucose tolerance and gastrointestinal hormone secretion in humans

Author:
Johnston, Kelly L., Clifford, Michael N., Morgan, Linda M.
Source:
Journal of the science of food and agriculture 2002 v.82 no.15 pp. 1800-1805
ISSN:
0022-5142
Subject:
apple juice, blood glucose, gastrointestinal system, glucagon-like peptide 1, glucose, glucose tolerance, hormone secretion, humans, insulin, intestinal absorption, phloridzin, polyphenols, volunteers
Abstract:
The purpose of this study was to investigate whether naturally occurring phenolic compounds in apple juice had any physiological effects on plasma glucose concentrations and circulating gastrointestinal hormone profiles in volunteers. The results show that the consumption of a 25 g glucose load in commercial apple juice compared with that consumed in water has statistically significant effects on plasma concentrations of glucose, insulin, GIP and GLP-1 in volunteers (N = 9) which appear to be consistent with delayed intestinal absorption of glucose. The exact mechanisms require further investigation but, tentatively, it is suggested that phloridzin and other polyphenols may be responsible.
Agid:
385886