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Evaluation of compound 48/80 as a model of immediate hypersensitivity in the skin of dogs
- MASON, IAN S., LLOYD, DAVID H.
- Veterinary dermatology 1996 v.7 no.2 pp. 81-83
- atopic dermatitis, biopsy, dogs, injection site, mast cells, models, veterinary medicine
- The macroscopic and histological effects of intradermal injection of compound 48/80 were investigated in dogs. Dose‐dependent increases in skin‐fold thickness were induced at injection sites and histopathological examination of skin biopsy specimens revealed evidence of mast cell degranulation and cellular infiltration. Intradermal compound 48/80 may form a useful model for studies of canine hypersensitivity disorders including atopic dermatitis.