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Absence of Serotype-Specific Surface Antigen in Laboratory Variants of Epidemic-Associated Listeria monocytogenes Strains

Author:
Cheng, Ying, Yue, Lili, Elhanafi, Driss, Kathariou, S.
Source:
Applied and environmental microbiology 2007 v.73 no.19 pp. 6313-6316
ISSN:
0099-2240
Subject:
Listeria monocytogenes, bacteriophages, clones, monoclonal antibodies, serotypes, surface antigens
Abstract:
Variants that lacked reactivity with the serotype 4b-specific monoclonal antibody c74.22 and that lost susceptibility to certain Listeria- or serotype 4b-specific phages were identified in the course of genetic studies with serotype 4b Listeria monocytogenes strains H7550 and F2381L (epidemic clones I and II, respectively). Our findings suggest that such variants can become inadvertently established under laboratory conditions and suggest caution in work involving serotype 4b strains and genetic constructs thereof.
Agid:
399882