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Synthesis of macrolides with N-containing (azine or hydrazide) groups
- Ishmuratov, G. Yu., Yakovleva, M. P., Mingaleeva, G. R., Muslukhov, R. R., Vyrypaev, E. M., Galkin, E. G., Ivanov, S. P., Tolstikov, A. G.
- Chemistry of natural compounds 2009 v.45 no.4 pp. 465-469
- azines, dicarboxylic acids, hydrazides, hydrazine, macrolides, temperature
- Potentially useful 17-, and 22÷25-membered macrolides containing azine or hydrazide groups were synthesized from tetrahydropyran via [1+1]-condensation at room temperature of 7-oxooctyl-7-oxooctanoate, which was obtained via Tishchenko reaction from 7-oxooctanal, with hydrazine hydrate and hydrazides of several dicarboxylic acids.