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Comparative Toxicokinetics, Absolute Oral Bioavailability, and Biotransformation of Zearalenone in Different Poultry Species

Author:
Devreese, Mathias, Antonissen, Gunther, Broekaert, Nathan, Baere, Siegrid de, Vanhaecke, Lynn, Backer, Patrick de, Croubels, Siska
Source:
Journal of agricultural and food chemistry 2015 v.63 no.20 pp. 5092-5098
ISSN:
0021-8561
Subject:
bioavailability, biotransformation, broiler chickens, intravenous injection, laying hens, pharmacokinetics, poults, turkeys, zearalenone
Abstract:
After oral (PO) and intravenous (IV) administration of zearalenone (ZEN) to broiler chickens, laying hens, and turkey poults, the mycotoxin was rapidly absorbed (T max = 0.32-0.97 h) in all three species; however, the absolute oral bioavailability was low (F% = 6.87-10.28%). Next, also a rapid elimination of the mycotoxin in all poultry species was observed (T 1/2el = 0.29-0.46 h). Both α- and β-zearalenone (ZEL) were formed equally after IV administration in all species studied, whereas an increased biotransformation to β-ZEL was demonstrated after PO administration, indicating presystemic biotransformation mainly in broiler chickens and laying hens. In comparison to the latter, turkey poults demonstrated a more extensive biotransformation of ZEN to α-ZEL after PO administration which could, in combination with the observed higher volume of distribution of ZEN, indicate a higher sensitivity of this species to the effects of ZEN in comparison to other poultry species.
Agid:
4155107