Jump to Main Content
Comparative Toxicokinetics, Absolute Oral Bioavailability, and Biotransformation of Zearalenone in Different Poultry Species
- Devreese, Mathias, Antonissen, Gunther, Broekaert, Nathan, Baere, Siegrid de, Vanhaecke, Lynn, Backer, Patrick de, Croubels, Siska
- Journal of agricultural and food chemistry 2015 v.63 no.20 pp. 5092-5098
- bioavailability, biotransformation, broiler chickens, intravenous injection, laying hens, pharmacokinetics, poults, turkeys, zearalenone
- After oral (PO) and intravenous (IV) administration of zearalenone (ZEN) to broiler chickens, laying hens, and turkey poults, the mycotoxin was rapidly absorbed (T max = 0.32-0.97 h) in all three species; however, the absolute oral bioavailability was low (F% = 6.87-10.28%). Next, also a rapid elimination of the mycotoxin in all poultry species was observed (T 1/2el = 0.29-0.46 h). Both Î±- and Î²-zearalenone (ZEL) were formed equally after IV administration in all species studied, whereas an increased biotransformation to Î²-ZEL was demonstrated after PO administration, indicating presystemic biotransformation mainly in broiler chickens and laying hens. In comparison to the latter, turkey poults demonstrated a more extensive biotransformation of ZEN to Î±-ZEL after PO administration which could, in combination with the observed higher volume of distribution of ZEN, indicate a higher sensitivity of this species to the effects of ZEN in comparison to other poultry species.