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Two new diterpenes from the seeds of Caesalpinia minax Hance

Author:
Lian, Lian, Li, Xiao-Bin, Yuan, Jiu-Zhi, Cheng, Li, Wu, Zhao-Hua, Gao, Hui-Yuan
Source:
Journal of Asian natural products research 2015 v.17 no.9 pp. 893-899
ISSN:
1477-2213
Subject:
Caesalpinia, anti-inflammatory activity, chemical structure, diterpenoids, lipopolysaccharides, macrophages, nitric oxide, nuclear magnetic resonance spectroscopy, seeds
Abstract:
Molecules with diterpene skeletons often possess valuable medicinal properties. Two new diterpenes 1α,6α,7β-triacetoxy-5α-hydroxy-14β-ethyl- O -vouacapane (1) and 2α-acetoxy-14,15-cyclopimara-7β,16-diol (2) were isolated from the seeds of Caesalpinia minax Hance. Their structures were established on the basis of extensive spectroscopic analyses, including HR-ESI-MS, UV, IR, 1D, and 2D NMR (HSQC, HMBC, NOESY) methods. The stereochemical structure of 1 was confirmed via the circular dichroism spectrum and calculated ECD experiment. The inhibitory activity of nitric oxide production of RAW264.7 macrophages stimulated by lipopolysaccharide of compounds 1 and 2 was evaluated, and compound 1 was found to show significant inhibitory effect.
Agid:
4163166