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Two new triterpenoid saponins from Ilex cornuta
- Wang, Ming-Lei, Liu, Yan-Li, Xu, Qiong-Ming, Li, Yun-Qiu, Yang, Shi-Lin
- Journal of Asian natural products research 2015 v.17 no.9 pp. 908-914
- Ilex cornuta, cardiomyocytes, chemical structure, electrospray ionization mass spectrometry, hydrolysis, nuclear magnetic resonance spectroscopy, protective effect, stems, triterpenoid saponins
- Two new triterpenoid saponins (1 and 2) were isolated from the stems of Ilex cornuta , along with two known triterpenoids (3 and 4). The structures of compounds 1 and 2 were determined as ursane-12,19-diene-28-oic acid 3β- O -β- d -glucuronopyranoside-6- O -methyl ester (1), 3α,23α-dihydroxy-olean-9(11),12-diene-28-oic acid 28- O -β- d -glucopyranosyl ester (2), on the basis of hydrolysis and spectral evidence, including 1D and 2D NMR and high resolution electrospray ionization mass spectrometry (HR-ESI-MS) analyses. Protective effects of compounds 1 – 4 were tested against H ₂O ₂-induced H9c2 cardiomyocyte injury, and the data showed that all these compounds had no cell-protective effect.