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Protective effect of white tea extract against acute oxidative injury caused by adriamycin in different tissues

Author:
Espinosa, Cristóbal, López-Jiménez, José Ángel, Cabrera, Lorena, Larqué, Elvira, Almajano, María Pilar, Arnao, Marino B., Zamora, Salvador, Pérez-Llamas, Francisca
Source:
Food chemistry 2012 v.134 no.4 pp. 1780-1785
ISSN:
0308-8146
Subject:
antioxidant activity, body weight, brain, drugs, heart, lipids, liver, long term effects, microsomes, oxidative stress, protective effect, proteins, rats, tea
Abstract:
Adriamycin (ADR) is an anticancer agent that increases oxidative stress in cells. We evaluated the protective effect of the long term consumption of white tea at two different doses against this drug. For this purpose rats were given distilled water (controls), 0.15mg (Dose 1) or 0.45mg (Dose 2) of solid tea extract/kg body weight for 12months. All the animals received an injection of ADR, except half of the control group, which were given an injection of saline solution. This gave four experimental groups: Control (C), C+ADR, Dose 1+ADR, and Dose 2+ADR. The antioxidant activity (in liver, heart and brain microsomes) was analysed. White tea consumption for 12months, at a non-pharmacological dose, reversed the oxidative damage caused by ADR, on both protein and lipid levels in all three organs. The heart recovered its antioxidant activity only at the highest dose of tea.
Agid:
417004