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New Class of Algicidal Compounds and Fungicidal Activities Dervied from a Chromene Amide of Amyris texana
- Author:
- Meepagala, Kumudini
- Source:
- Journal of Agricultural and Food Chemistry 2010
- ISSN:
- 1520-5118
- Subject:
- Amyris, Colletotrichum, Ictalurus punctatus, Planktothrix, algicides, amides, amines, antifungal properties, bioassays, leaf extracts, off flavors, phytotoxicity, salts, water solubility
- Abstract:
- A chromene amide, N-[2-(2,2-dimethyl-2H-1-benzopyran-6-yl)ethyl]-N,3-dimethylbutanamide, was isolated from the EtOAc extract of the leaves of Amyris texana and found to have moderate antifungal activity against Colletotrichum spp. and selective algicidal activity against Planktothrix perornata, a cyanobacterium (blue-green alga) that causes musty off-flavor in farm-raised channel catfish (Ictalurus punctatus). To improve the selective algicidal activity and provide water solubility, a series of chromene analogues were synthesized and evaluated for algicidal activity using a 96-well microplate rapid bioassay. In addition, the chromene analogues were evaluated for antifungal and phytotoxic activities. Hydrochloride salts of a chromene amine analogue showed improved water solubility and selectivity toward P. perornata with activity comparable to that of the naturally occurring chromene amide.
- Agid:
- 426131
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