PubAg

New Class of Algicidal Compounds and Fungicidal Activities Dervied from a Chromene Amide of Amyris texana

Author:

Meepagala, Kumudini

Source:

Journal of Agricultural and Food Chemistry 2010

ISSN:

1520-5118

Subject:

Amyris, Colletotrichum, Ictalurus punctatus, Planktothrix, algicides, amides, amines, antifungal properties, bioassays, leaf extracts, off flavors, phytotoxicity, salts, water solubility

Abstract:

A chromene amide, N-[2-(2,2-dimethyl-2H-1-benzopyran-6-yl)ethyl]-N,3-dimethylbutanamide, was isolated from the EtOAc extract of the leaves of Amyris texana and found to have moderate antifungal activity against Colletotrichum spp. and selective algicidal activity against Planktothrix perornata, a cyanobacterium (blue-green alga) that causes musty off-flavor in farm-raised channel catfish (Ictalurus punctatus). To improve the selective algicidal activity and provide water solubility, a series of chromene analogues were synthesized and evaluated for algicidal activity using a 96-well microplate rapid bioassay. In addition, the chromene analogues were evaluated for antifungal and phytotoxic activities. Hydrochloride salts of a chromene amine analogue showed improved water solubility and selectivity toward P. perornata with activity comparable to that of the naturally occurring chromene amide.

Agid:

426131