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Diffusion of Macromolecules in Model Oral Biofilms
- Takenaka, Shoji, Pitts, Betsey, Trivedi, Harsh M., Stewart, Philip S.
- Applied and environmental microbiology 2009 v.75 no.6 pp. 1750-1753
- biofilm, green fluorescent protein, immunoglobulin G, proteinases, solutes
- The diffusive penetration of fluorescently tagged macromolecular solutes into model oral biofilms was visualized by time-lapse microscopy. All of the solutes tested, including dextrans, proteases, green fluorescent protein, and immunoglobulin G, accessed the interior of cell clusters 100 to 200 μm in diameter within 3 min or less.