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Ratio of âA-typeâ to âB-typeâ Proanthocyanidin Interflavan Bonds Affects Extra-intestinal Pathogenic Escherichia coli Invasion of Gut Epithelial Cell
- Feliciano, Rodrigo P., Meudt, Jennifer J., Shanmuganayagam, Dhanansayan, Krueger, Christian G., Reed, Jess D.
- Journal of agricultural and food chemistry 2014 v.62 no.18 pp. 3919-3925
- risk, apples, proanthocyanidins, bioactive properties, septicemia, urinary tract diseases, cranberries, agglutination, enterocytes, Escherichia coli
- Gut colonization by extra-intestinal pathogenic Escherichia coli (ExPEC) increases the risk of subsequent infections, including urinary tract infection and septicemia. Previous work suggests that cranberry proanthocyanidins (PAC) interact with bacterial surface factors, altering bacterial interaction with host cells. Methods were developed to determine if ratios of âA-typeâ to âB-typeâ interflavan bonds in PAC affect ExPEC agglutination and invasion of enterocytes. In cranberries, 94.5% of PAC contain one or more âA-typeâ bonds, whereas in apples, 88.3% of PAC contain exclusively âB-typeâ bonds. Results show that cranberry âA-typeâ PAC have greater bioactivity than apple âB-typeâ PAC for increasing ExPEC agglutination and decreasing ExPEC epithelial cell invasion.