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Hepatoprotective Sesquiterpenes and Rutinosides from Murraya koenigii (L.) Spreng

Author:
Ma, Qin-Ge, Wang, Yan-Gai, Liu, Wen-Min, Wei, Rong-Rui, Yang, Jian-Bo, Wang, Ai-Guo, Ji, Teng-Fei, Tian, Jin, Su, Ya-Lun
Source:
Journal of agricultural and food chemistry 2014 v.62 no.18 pp. 4145-4151
ISSN:
0021-8561
Subject:
Bergera koenigii, hepatoprotective effect, leaves, sesquiterpenoids, spectral analysis
Abstract:
Three new sesquiterpenes (1–3) and two new rutinosides (4 and 5) along with 17 known compounds (6–22) were isolated from the leaves of Murraya koenigii (L.) Spreng. The new compounds were elucidated as (3R,5S,6R)-3,5,6-trihydroxy-1,1,5-trimethylcyclohexyl-8-butyn-9-one (1), (8E,9R)-ethyl-7-(3S,5R,6S)-3,6-dihydroxy-1,1,5-trimethylcyclohexyl-9-hydroxybut-8-enoate (2), (3R)-3-O-β-d-glucoside-6′-d-apiose-β-ionone (3), 4-O-β-d-rutinosyl-3-methoxyphenyl-1-propanone (4), and 1-O-β-d-rutinosyl-2(R)-ethyl-1-pentanol (5) based on their spectroscopic data. Compounds 1, 4, 5, 18, and 21 (10 μM) exhibited moderate hepatoprotective activities.
Agid:
4321692