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The sedative effects of intramuscular low-dose medetomidine in combination with butorphanol or methadone in dogs
- Puighibet, Zoë, Costa-Farré, Cristina, Santos, Laura, Canfrán, Susana, Gómez de Segura, Ignacio A
- Veterinary anaesthesia and analgesia 2015 v.42 no.6 pp. 590-596
- adults, butorphanol, catheters, dogs, heart rate, medetomidine, methadone, randomized clinical trials, respiratory rate, sedation, sedatives, temperature
- To compare the sedative effects of an intramuscular (IM) low dose of medetomidine in combination with butorphanol or methadone in dogs.Prospective, blinded, randomized clinical trial.Forty-eight healthy adult dogs that required sedation for diagnostic or surgical elective procedures.Dogs were sedated IM with medetomidine (2.5 μg kg−1) and either butorphanol (0.4 mg kg−1) or methadone (0.4 mg kg−1). The degree of sedation was assessed every 10 minutes, for 30 minutes, using a numeric descriptive scale. Data on heart rate (HR), respiratory rate, capillary refill time, temperature and response to a toe pinch were recorded. The response to venous catheterization at minute 30 was also evaluated.Both combinations produced moderate to deep sedation with a maximal effect at 20–30 minutes without significant differences in the degree of sedation between the treatments at any studied time-point. HR decreased from minute 10 to minute 30 with both opioid combinations (p < 0.05); this reduction did not differ between groups (p > 0.05). No differences between groups were detected in any of the other variables.Combinations of a low dose of medetomidine with butorphanol or methadone, respectively, provide similar degrees of sedation.