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Effect of a dietary copper deficiency on plasma fibrinolytic activity in male and female mice
- Lynch, Sean M., Klevay, Leslie M.
- Nutrition research 1993 v.13 no.8 pp. 913
- diet, copper, fibrinolysis, dietary minerals, nutrient deficiencies, experimental diets, blood plasma, blood coagulation factors, heart, liver, mice
- To investigate the effects of a dietary Cu deficiency on plasma fibrinolytic activity, groups (n = 16) of adult male and female Swiss-Webster mice were fed Cu-supplemented (8.4 mg Cu/kg) or Cu-deficient (0.3 mg Cu/kg) diets ad libitum with deionized water for 43-49 days. Animals were exsanguinated under pentobarbital anaesthesia; platelet-poor plasma was prepared and assayed for euglobulin clot lysis time (ECLT). Plasma protein C (PC) and antithrombin III (AT-III) activities also were determined. No statistically significant effect of Cu deficiency on either PC or AT-III activity was observed but a highly significant (P < 0.001) ECLT prolongation in both male and female deficient mice clearly demonstrated that the physiological clot-lysing mechanism must be impaired in these animals. These results may help to explain the thrombotic sequelae of a dietary Cu deficiency in mice.