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Location of mouse and human genes corresponding to conserved canine olfactory receptor gene subfamilies

Carver, Ethan A., Issel-Tarver, Laurie, Rine, Jasper, Olsen, Anne S., Stubbs, Lisa
Mammalian genome 1998 v.9 no.5 pp. 349-354
G-protein coupled receptors, chromosomes, dogs, epithelium, humans, mice, multigene family, nose, odor compounds, olfactory receptors
Olfactory receptors are G protein-coupled, seven-transmembrane-domain proteins that are responsible for binding odorants in the nasal epithelium. They are encoded by a large gene family, members of which are organized in several clusters scattered throughout the genomes of mammalian species. Here we describe the mapping of mouse sequences corresponding to four conserved olfactory receptor genes, each representing separate, recently identified canine gene subfamilies. Three of the four canine genes detected related gene clusters in regions of mouse Chromosomes (Chrs) 2, 9, and 10, near previously mapped mouse olfactory genes, while one detected a formerly unidentified gene cluster located on mouse Chr 6. In addition, we have localized two human gene clusters with homology to the canine gene, CfOLF4, within the established physical map of Chr 19p. Combined with recently published studies, these data link the four conserved olfactory gene subfamilies to homologous regions of the human, dog, and mouse genomes.